SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES
نویسندگان: ثبت نشده
چکیده مقاله:
The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylation and subsequent oxidation of 4 gave 6. The antibacterial and antifungal activities of 6a to 6f against a number of microorganisms were determined. Only compounds 6b and 6c had moderate activity against Aspergilus niger
منابع مشابه
syntheses, antifungal and antibacterial activities of substituted 1,2, ctrimoles
the reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. the reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3h- l,2,4-triazole-3- thione 4. alkylation an...
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عنوان ژورنال
دوره 9 شماره 1
صفحات -
تاریخ انتشار 1998-03-01
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